Target-activated cascade transcription amplification lights up RNA aptamers for label-free detection of metalloproteinase-2 activity. Issue 8 (6th January 2023)
- Record Type:
- Journal Article
- Title:
- Target-activated cascade transcription amplification lights up RNA aptamers for label-free detection of metalloproteinase-2 activity. Issue 8 (6th January 2023)
- Main Title:
- Target-activated cascade transcription amplification lights up RNA aptamers for label-free detection of metalloproteinase-2 activity
- Authors:
- Zhao, Ning-ning
Liu, Wen-jing
Tian, Xiaorui
Zhang, Baogang
Zhang, Chun-yang - Abstract:
- Abstract : Target-activated cascade transcription amplification lights up RNA aptamers for label-free detection of metalloproteinase-2 activity with zero background. Abstract : We demonstrate that target-activated cascade transcription amplification lights up RNA aptamers for label-free detection of metalloproteinase-2 (MMP-2) activity with zero background. This assay exhibits good specificity and high sensitivity with a limit of detection (LOD) of 0.6 fM. Moreover, it can analyze enzyme kinetic parameters, screen inhibitors, and accurately quantify MMP-2 in cancer cells and clinical serums.
- Is Part Of:
- Chemical communications. Volume 59:Issue 8(2023)
- Journal:
- Chemical communications
- Issue:
- Volume 59:Issue 8(2023)
- Issue Display:
- Volume 59, Issue 8 (2023)
- Year:
- 2023
- Volume:
- 59
- Issue:
- 8
- Issue Sort Value:
- 2023-0059-0008-0000
- Page Start:
- 1058
- Page End:
- 1061
- Publication Date:
- 2023-01-06
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d2cc06784f ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
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- 25179.xml