ROS-scavenging biomaterials for periodontitis. Issue 3 (5th December 2022)

• Record Type: Journal Article
• Authors: Chen, Enni; Wang, Tianyou; Tu, Yuan; Sun, ZhiYuan; Ding, Yi; Gu, Zhipeng; Xiao, Shimeng
• Is Part Of: Journal of materials chemistry. Volume 11:Issue 3(2022)
• Page Start: 482
• Page End: 499
• Publication Date: 2022-12-05
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d2tb02319a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Oxidative stress induced by the imbalance from periodontal pathogens is the main inducement for periodontal tissue destruction, and ROS scavenging biomaterials could be the promising candidate for periodontitis therapy. Abstract : Periodontitis is defined as a chronic inflammatory disease in which the continuous activation of oxidative stress surpasses the reactive oxygen species (ROS) scavenging capacity of the endogenous antioxidative defense system. Studies have demonstrated that ROS-scavenging biomaterials should be promising candidates for periodontitis therapy. To benefit the understanding and design of scavenging biomaterials for periodontitis, this review details the relationship between ROS and periodontitis, including direct and indirect damage, the application of ROS-scavenging biomaterials in periodontitis, including organic and inorganic ROS-scavenging biomaterials, and the various dosage forms of fabricated materials currently used for periodontal therapy. Finally, the current situation and further prospects of ROS-scavenging biomaterials in periodontal applications are summarized. Expecting that improved ROS-scavenging biomaterials could be better designed and developed for periodontal and even clinical application.