PD-1 Inhibitor for Disseminated Mycobacterium avium Infection in a Person With HIV. (28th December 2022)

• Record Type: Journal Article
• Authors: Liu, Li; Song, Zichen; Xun, Jingna; Liu, Danping; Wei, Jianhao; Wang, Zhenyan; Tang, Yang; Sun, Jianjun; Chen, Jun
• Is Part Of: Open forum infectious diseases. Volume 10:Number 1(2023)
• Publication Date: 2022-12-28
• Subjects: HIV -- immunotherapy -- mycobacteria -- Mycobacterium avium -- PD-1 blockade; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac700
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We report a case of a person with human immunodeficiency virus with disseminated Mycobacterium avium infection, in whom antiretroviral therapy combined with all drugs of anti– M avium activity failed to clear the pathogen. After PD-1 inhibitor treatment, T-cell exhaustion was reversed and M avium –specific T-cell response was boosted, together with M avium clearance.