Pathology Consultation on HbA1c Methods and Interferences. Issue 1 (1st January 2014)

• Record Type: Journal Article
• Authors: Rhea, Jeanne M.; Molinaro, Ross
• Is Part Of: American journal of clinical pathology. Volume 141:Issue 1(2014)
• Page Start: 5
• Page End: 16
• Publication Date: 2014-01-01
• Subjects: HbA1c methods -- Blood glucose concentrations -- Diabetes -- HbA1c interferences -- HbA1c interpretation; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1309/AJCPQ23GTTMLAEVL
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objectives: To review the various hemoglobin (Hb) A1c methods, with a focus on interferences resulting from Hb variants. Methods: HbA1c is a marker used for the diagnosis and management of diabetes. Each available HbA1c method has advantages and challenges, such as its susceptibility to interferences. Results: The presence of Hb variants and/or abnormalities in RBC turnover cannot only interfere analytically with HbA1c measurements but also may affect the clinical interpretation of HbA1c values. Conclusions: Familiarity with the advantages and challenges of the various methods used for HbA1c testing is essential when establishing therapeutic management and goals based on HbA1c results, especially in populations with a high prevalence of Hb variants.