Cancer risk among HIV-exposed uninfected children in the United States. (1st March 2023)

• Record Type: Journal Article
• Authors: Horner, Marie-Josèphe; Hazra, Rohan; Barnholtz-Sloan, Jill S.; Shiels, Meredith S.; Engels, Eric A.
• Is Part Of: AIDS. Volume 37:Number 3(2023)
• Page Start: 549
• Page End: 551
• Publication Date: 2023-03-01
• Subjects: AIDS (Disease) -- Periodicals; Acquired Immunodeficiency Syndrome; AIDS (Disease); Periodicals; Periodicals; 616.9792005
• DOI: 10.1097/QAD.0000000000003458
• Languages: English
• ISSNs: 0269-9370

Abstract

Abstract : In utero exposure to didanosine was associated with increased risk of brain cancer in a French study. We used United States health department records to assess cancer risk among 13 617 children exposed to HIV in utero, who remained HIV-uninfected after birth (1990–2017). Risk of brain tumors was borderline elevated among these children (standardized incidence ratio 2.2, 95% confidence interval 0.8–4.8, P = 0.12, based on six cases). Risk was not significantly increased for leukemia or other cancers.