Enrollment of Racial and Ethnic Minoritized Groups in Gynecologic Oncology Clinical Trials: A Review of the Scope of the Problem, Contributing Factors, and Strategies to Improve Inclusion. Issue 1 (21st March 2023)

• Record Type: Journal Article
• Authors: Barry, Danika; Steinberg, Jecca R.; Towner, Mary; Barber, Emma L.; Simon, Melissa A.; Roque, Dario R.
• Is Part Of: Clinical obstetrics and gynecology. Volume 66:Issue 1(2023)
• Page Start: 22
• Page End: 35
• Publication Date: 2023-03-21
• Subjects: clinical trials -- gynecologic oncology -- diversity; Obstetrics -- Periodicals; Gynecology -- Periodicals; Obstétrique -- Périodiques; Gynécologie -- Périodiques; 618.05
• DOI: 10.1097/GRF.0000000000000765
• Languages: English
• ISSNs: 0009-9201

Abstract

Abstract : Racial inequities are well-documented across the gynecologic oncology care continuum, including the representation of racial and ethnic minoritized groups (REMGs) in gynecologic oncology clinical trials. We specifically reviewed the scope of REMG disparities, contributing factors, and strategies to improve inclusion. We found systematic and progressively worsening under-enrollment of REMGs, particularly of Black and Latinx populations. In addition, race/ethnicity data reporting is poor, yet a prerequisite for accountability to recruitment goals. Trial participation barriers are multifactorial, and successful remediation likely requires multi-level strategies. More rigorous, transparent data on trial participants and effectiveness studies on REMG recruitment strategies are needed to improve enrollment.