Remdesivir Resistance in Transplant Recipients With Persistent Coronavirus Disease 2019. (26th September 2022)

• Record Type: Journal Article
• Authors: Hogan, John I; Duerr, Ralf; Dimartino, Dacia; Marier, Christian; Hochman, Sarah E; Mehta, Sapna; Wang, Guiqing; Heguy, Adriana
• Is Part Of: Clinical infectious diseases. Volume 76:Number 2(2023)
• Page Start: 342
• Page End: 345
• Publication Date: 2022-09-26
• Subjects: antiviral resistance -- severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) -- immunocompromise -- remdesivir -- solid-organ transplant; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciac769
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: New mutations conferring resistance to SARS-CoV-2 therapeutics have important clinical implications. We describe the first cases of an independently acquired V792I RNA-dependent RNA polymerase mutation developing in renal transplant recipients after remdesivir exposure. Our work underscores the need for augmented efforts to identify concerning mutations and address their clinical implications.