Social-interactive reward elicits similar neural response in autism and typical development and predicts future social experiences. (February 2023)

• Record Type: Journal Article
• Authors: McNaughton, Kathryn A.; Kirby, Laura Anderson; Warnell, Katherine Rice; Alkire, Diana; Merchant, Junaid S.; Moraczewski, Dustin; Yarger, Heather A.; Thurm, Audrey; Redcay, Elizabeth
• Is Part Of: Developmental cognitive neuroscience. Volume 59(2023)
• Publication Date: 2023-02
• Subjects: VS Ventral Striatum -- AUT Autism -- TD Typical Development; Autism -- Social interaction -- Social reward -- fMRI -- Ventral striatum; Cognitive neuroscience -- Periodicals; Developmental neurobiology -- Periodicals; Neuropsychology -- Periodicals; Neuropsychiatry -- Periodicals; 612.8233
• DOI: 10.1016/j.dcn.2023.101197
• Languages: English
• ISSNs: 1878-9293

Abstract

Abstract: Challenges in initiating and responding to social-interactive exchanges are a key diagnostic feature of autism spectrum disorder, yet investigations into the underlying neural mechanisms of social interaction have been hampered by reliance on non-interactive approaches. Using an innovative social-interactive neuroscience approach, we investigated differences between youth with autism and youth with typical development in neural response to a chat-based social-interactive reward, as well as factors such as age and self-reported social enjoyment that may account for heterogeneity in that response. We found minimal group differences in neural and behavioral response to social-interactive reward, and variation within both groups was related to self-reported social enjoyment during the task. Furthermore, neural sensitivity to social-interactive reward predicted future enjoyment of a face-to-face social interaction with a novel peer. These findings have important implications for understanding the nature of social reward and peer interactions in typical development as well as for future research informing social interactions in individuals on the autism spectrum. Highlights: We used a social-interactive fMRI task to investigate social reward. We examined groups with autism (AUT) and typical development (TD). We found minimal differences between groups in social-interactive reward processing. Heterogeneity in neural response related to self-reported enjoyment of the task. Neural response predicted future social interaction enjoyment with a novel peer.