Correction and Prevention of Hyponatremia in Patients With Cirrhosis and Ascites: Post Hoc Analysis of the ANSWER Study Database. (6th September 2022)

• Record Type: Journal Article
• Authors: Zaccherini, Giacomo; Baldassarre, Maurizio; Tufoni, Manuel; Nardelli, Silvia; Piano, Salvatore; Alessandria, Carlo; Neri, Sergio; Foschi, Francesco Giuseppe; Levantesi, Fabio; Bedogni, Giorgio; Domenicali, Marco; Bernardi, Mauro; Caraceni, Paolo
• Is Part Of: American journal of gastroenterology. Volume 118:Number 1(2023)
• Page Start: 168
• Page End: 173
• Publication Date: 2022-09-06
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000001995
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : INTRODUCTION: We assessed the impact of long-term albumin administration to hyponatremic patients with ascites enrolled in the ANSWER trial. METHODS: The normalization rate of baseline hyponatremia and the 18-month incidence rate of at least moderate hyponatremia were evaluated. RESULTS: The hyponatremia normalization rate was higher with albumin than with standard medical treatment (45% vs 28%, P = 0.042 at 1 month). Long-term albumin ensured a lower incidence of at least moderate hyponatremia than standard medical treatment (incidence rate ratio: 0.245 [CI 0.167–0.359], P < 0.001). DISCUSSION: Long-term albumin administration improves hyponatremia and reduces episodes of at least moderate hyponatremia in outpatients with cirrhosis and ascites.