Alcohol Consumption by Beverage Type and Risk of Breast Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies. (22nd February 2020)

• Record Type: Journal Article
• Authors: Sun, Qiuyu; Xie, Weihong; Wang, Yanli; Chong, Feifei; Song, Mengmeng; Li, Tiandong; Xu, Linping; Song, Chunhua
• Is Part Of: Alcohol and alcoholism. Volume 55:Number 3(2020)
• Page Start: 246
• Page End: 253
• Publication Date: 2020-02-22
• Subjects: Alcoholism -- Periodicals; 616.861005
• DOI: 10.1093/alcalc/agaa012
• Languages: English
• ISSNs: 0735-0414

Abstract

Abstract: Aims: Alcohol intake has been shown to increase the risk of breast cancer. However, the dose-response analysis of different alcoholic beverages (spirits, wine and beer) is not clear. Our meta-analysis aims to provide a dose-response estimation between different alcohols and breast cancer risk. Methods: Search of PubMed and Web of Science and manual searches were conducted up to 1 December 2018, and summary relative risks ( RRs ) and attributable risk percentage (ARP) for alcohol intake on the development of breast cancer were calculated. Dose-response meta-analysis modeled relationships between drinking type and breast cancer risk. Sources of heterogeneity were explored, and sensitivity analyses were conducted to test the robustness of findings. Results: In total, 22 cohort studies and 45, 350 breast cancer cases were included. Current drinkers for ER+ had an increased risk compared with never drinkers. In dose-response analysis, there was a statistically significant linear trend with breast cancer risk increasing gradually by total alcohol and wine dose: when adding 10 g per day, the risk increased by 10.5% ( RR = 1.10, 95% CI = 1.08–1.13) in total alcohol and 8.9% ( RR = 1.08, 95% CI = 1.04–1.14) in wine. For postmenopausal women, the risk increases by 11.1% ( RR = 1.11, 95% CI = 1.09–1.13) with every 10 g of total alcohol increase. Furthermore, the breast cancer alcohol-attributed percentage is higher in Europe than in North America and Asia. Conclusions: The effect of drinking on the incidence of breast cancer is mainly manifested in ER+ breast cancer. Quantitative analysis showed total drinking had a significant risk for breast cancer, especially for postmenopausal women. However, for different alcohols, just wine intake has the similar results.