Attenuated Post-Movement Beta Rebound Associated With Schizotypal Features in Healthy People. (18th September 2018)

• Record Type: Journal Article
• Authors: Hunt, Benjamin A E; Liddle, Elizabeth B; Gascoyne, Lauren E; Magazzini, Lorenzo; Routley, Bethany C; Singh, Krish D; Morris, Peter G; Brookes, Matthew J; Liddle, Peter F
• Is Part Of: Schizophrenia bulletin. Volume 45:Number 4(2019)
• Page Start: 883
• Page End: 891
• Publication Date: 2018-09-18
• Subjects: magnetoencephalography -- schizotypy -- schizophrenia -- individual differences -- schizotypal personality disorder -- psychosis; Schizophrenia -- Periodicals; Schizophrenia -- Research -- Periodicals; 616.898005
• DOI: 10.1093/schbul/sby117
• Languages: English
• ISSNs: 0586-7614

Abstract

Abstract: Introduction: Schizophrenia and schizotypal personality disorder (SPD) lie on a single spectrum of mental illness and converging evidence suggests similarities in the etiology of the 2 conditions. However, schizotypy is a heterogeneous facet of personality in the healthy population and so may be seen as a bridge between health and mental illness. Neural evidence for such a continuity would have implications for the characterization and treatment of schizophrenia. Based on our previous work identifying a relationship between symptomology in schizophrenia and abnormal movement-induced electrophysiological response (the post-movement beta rebound [PMBR]), we predicted that if subclinical schizotypy arises from similar neural mechanisms to schizophrenia, schizotypy in healthy individuals would be associated with reduced PMBR. Methods: One-hundred sixteen participants completed a visuomotor task while their neural activity was recorded by magnetoencephalography. Partial correlations were computed between a measure of PMBR extracted from left primary motor cortex and scores on the Schizotypal Personality Questionnaire (SPQ), a self-report measure of schizotypal personality. Correlations between PMBR and SPQ factor scores measuring cognitive-perceptual, interpersonal and disorganization dimensions of schizotypy were also computed. Effects of site, age, and sex were controlled for. Results: We found a significant negative correlation between total SPQ score and PMBR. This was most strongly mediated by variance shared between interpersonal and disorganization factor scores. Conclusion: These findings indicate a continuum of neural deficit between schizotypy and schizophrenia, with diminution of PMBR, previously reported in schizophrenia, also measurable in individuals with schizotypal features, particularly disorganization and impaired interpersonal relations.