The Biofilm Regulatory Network from Bacillus subtilis: A Structure-Function Analysis. Issue 3 (1st February 2023)

• Record Type: Journal Article
• Authors: Milton, Morgan E.; Cavanagh, John
• Is Part Of: Journal of molecular biology. Volume 435:Issue 3(2023)
• Publication Date: 2023-02-01
• Subjects: biofilms -- Bacillus subtilis -- transition state regulation -- protein structures; Molecular biology -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Bacteriology -- Periodicals; Molecular Biology -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biologie -- Périodiques; Biochimie -- Périodiques; Moleculaire biologie; Biochemistry; Biology; Molecular biology; Periodicals; 572.805
• DOI: 10.1016/j.jmb.2022.167923
• Languages: English
• ISSNs: 0022-2836

Abstract

Graphical abstract: Highlights: Current structural and biochemical knowledge of proteins involved in Bacillus subtilis biofilm regulation. B. subtilis biofilm formation has implications in human pathogen biofilms. Biofilm regulatory proteins are potential therapeutic intervention points. Abstract: Bacterial biofilms are notorious for their ability to protect bacteria from environmental challenges, most importantly the action of antibiotics. Bacillus subtilis is an extensively studied model organism used to understand the process of biofilm formation. A complex network of principal regulatory proteins including Spo0A, AbrB, AbbA, Abh, SinR, SinI, SlrR, and RemA, work in concert to transition B. subtilis from the free-swimming planktonic state to the biofilm state. In this review, we explore, connect, and summarize decades worth of structural and biochemical studies that have elucidated this protein signaling network. Since structure dictates function, unraveling aspects of protein molecular mechanisms will allow us to devise ways to exploit critical features of the biofilm regulatory pathway, such as possible therapeutic intervention. This review pools our current knowledge base of B. subtilis biofilm regulatory proteins and highlights potential therapeutic intervention points.