Evolutionary Modeling in SLiM 3 for Beginners. (24th December 2018)

• Record Type: Journal Article
• Authors: Haller, Benjamin C; Messer, Philipp W
• Editors: Hernandez, Ryan
• Is Part Of: Molecular biology and evolution. Volume 36:Number 5(2019)
• Page Start: 1101
• Page End: 1109
• Publication Date: 2018-12-24
• Subjects: modeling tutorial -- population genetic simulation -- QTL evolution; Molecular biology -- Periodicals; Molecular evolution -- Periodicals; Evolution, Molecular -- Periodicals; Molecular Biology -- Periodicals; 572.8
• DOI: 10.1093/molbev/msy237
• Languages: English
• ISSNs: 0737-4038

Abstract

Abstract: The SLiM forward genetic simulation framework has proved to be a powerful and flexible tool for population genetic modeling. However, as a complex piece of software with many features that allow simulating a diverse assortment of evolutionary models, its initial learning curve can be difficult. Here we provide a step-by-step demonstration of how to build a simple evolutionary model in SLiM 3, to help new users get started. We will begin with a panmictic neutral model, and build up to a model of the evolution of a polygenic quantitative trait under selection for an environmental phenotypic optimum.