Higher Prevalence of Frailty Among a Sample of HIV-Infected Middle-aged and Older Chinese Adults Is Associated With Neurocognitive Impairment and Depressive Symptoms. (16th March 2017)

• Record Type: Journal Article
• Authors: Ding, Yingying; Lin, Haijiang; Liu, Xing; Wong, Frank Y.; Sun, Yan V.; Marconi, Vincent C.; He, Na
• Is Part Of: Journal of infectious diseases. Volume 215:Number 5(2017:Mar. 01)
• Page Start: 687
• Page End: 692
• Publication Date: 2017-03-16
• Subjects: HIV infection -- frailty -- neurocognitive impairment -- depressive symptoms -- insomnia symptoms.; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jix032
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: We investigated the prevalence and correlates of prefrailty/frailty, determined on the basis of the Fried criteria, in Chinese patients with and those without human immunodeficiency virus (HIV) infection. HIV-infected patients were more likely to be frail or prefrail than controls, and this association remained significant after adjustment for potential confounders (odds ratio, 3.79). After additional adjustment for neurocognitive impairment and depressive and insomnia symptoms, this association remained significant but attenuated (odds ratio, 2.16). In the HIV-infected group, these 3 variables were independently associated with prefrailty/frailty. These findings suggest that neurocognitive impairment and depressive and/or insomnia symptoms may account for a higher prevalence of prefrailty/frailty in HIV-infected patients but require further longitudinal investigation.