Presence and stability of rotors in atrial fibrillation: evidence and therapeutic implications. (19th January 2016)

• Record Type: Journal Article
• Authors: Guillem, María S.; Climent, Andreu M.; Rodrigo, Miguel; Fernández-Avilés, Francisco; Atienza, Felipe; Berenfeld, Omer
• Is Part Of: Cardiovascular research. Volume 109:Number 4(2016)
• Page Start: 480
• Page End: 492
• Publication Date: 2016-01-19
• Subjects: Atrial fibrillation -- Body surface mapping -- Rotors -- Dominant frequency -- Fourier transform -- Phase mapping; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Periodicals; 616.1
• DOI: 10.1093/cvr/cvw011
• Languages: English
• ISSNs: 0008-6363

Abstract

Abstract: Rotor-guided ablation has opened new perspectives into the therapy of atrial fibrillation (AF). Analysis of the spatio-temporal cardiac excitation patterns in the frequency and phase domains has demonstrated the importance of rotors in research models of AF, however, the dynamics and role of rotors in human AF are still controversial. In this review, the current knowledge gained through research models and patient data that support the notion that rotors are key players in AF maintenance is summarized. We report and discuss discrepancies regarding rotor prevalence and stability in various studies, which can be attributed in part to methodological differences among mapping systems. Future research for validation and improvement of current clinical electrophysiology mapping technologies will be crucial for developing mechanistic-based selection and application of the best therapeutic strategy for individual AF patient, being it, pharmaceutical, ablative, or other approach.