Predictors of seizure outcomes in patients with diffuse low‐grade glioma‐related epilepsy after complete glioma removal. (13th December 2022)

• Record Type: Journal Article
• Authors: He, Xinghui; Zhang, Kai; Liu, Dingyang; Yang, Zhuanyi; Li, Xuejun; Yang, Zhiquan
• Is Part Of: CNS neuroscience & therapeutics. Volume 29:Number 2(2023)
• Page Start: 736
• Page End: 743
• Publication Date: 2022-12-13
• Subjects: diffuse low‐grade glioma -- diffuse low‐grade glioma‐related epilepsy -- epilepsy -- seizure outcomes; Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.14061
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract: Aims: We aimed to identify predictors of postoperative seizures in patients with diffuse low‐grade glioma (DLGG)‐related epilepsy after complete tumor resection in this study. Methods: We retrospectively collected data from individuals with DLGG‐related epilepsy whose tumors were completely resected at Xiangya Hospital, Central South University between January 2014 and January 2020. The predictors of seizure outcomes were assessed by employing univariate analysis and a multivariate logistic regression model in a backward binary logistic regression model. Results: Among the 118 cases that met the inclusion criteria, 83.05% were seizure‐free following an average follow‐up of 4.27 ± 1.65 years, all of whom were classified as International League Against Epilepsy class I outcome. Univariate and multivariate analyses indicated that seizure duration of >6 years (odds ratio [OR], 6.62; 95% confidence interval [CI], 1.76–24.98; p = 0.005) and first clinical symptoms other than seizures (OR, 4.51; 95% CI, 1.43–14.23; p = 1.010) were both independent predictors of unfavorable seizure outcomes. Conclusion: Our results imply that satisfactory seizure outcomes can be achieved in most patients with DLGG‐related epilepsy after complete tumor resection. Patients with seizure duration of >6 years or first clinical symptoms other than seizures were more likely to experience postoperative seizure recurrence. Abstract : Our study revealed that seizure duration greater than 6 years or first clinical symptoms other than seizures were independent predictors of unfavorable seizure outcomes in patients with diffuse low‐grade glioma‐related epilepsy after complete tumor removal.