Abnormal brain functional network dynamics in sleep‐related hypermotor epilepsy. (12th December 2022)

• Record Type: Journal Article
• Authors: Wan, Xinyue; Zhang, Pengfei; Wang, Weina; Wu, Xintong; Tan, Qiaoyue; Su, Xiaorui; Zhang, Simin; Yang, Xibiao; Li, Shuang; Shao, Hanbing; Yue, Qiang; Gong, Qiyong
• Is Part Of: CNS neuroscience & therapeutics. Volume 29:Number 2(2023)
• Page Start: 659
• Page End: 668
• Publication Date: 2022-12-12
• Subjects: dynamic functional network connectivity -- independent component analysis -- network‐based statistics -- resting‐state functional magnetic resonance imaging -- sleep‐related hypermotor epilepsy; Neuropharmacology -- Periodicals; Central nervous system -- Diseases -- Effect of drugs on -- Periodicals; 612.8
• DOI: 10.1111/cns.14048
• Languages: English
• ISSNs: 1755-5930

Abstract

Abstract: Aims: This study aimed to use resting‐state functional magnetic resonance imaging (rs‐fMRI) to determine the temporal features of functional connectivity states and changes in connectivity strength in sleep‐related hypermotor epilepsy (SHE). Methods: High‐resolution T1 and rs‐fMRI scanning were performed on all the subjects. We used a sliding‐window approach to construct a dynamic functional connectivity (dFC) network. The k‐means clustering method was performed to analyze specific FC states and related temporal properties. Finally, the connectivity strength between the components was analyzed using network‐based statistics (NBS) analysis. The correlations between the abovementioned measures and disease duration were analyzed. Results: After k‐means clustering, the SHE patients mainly exhibited two dFC states. The frequency of state 1 was higher, which was characterized by stronger connections within the networks; state 2 occurred at a relatively low frequency, characterized by stronger connections between networks. SHE patients had greater fractional time and a mean dwell time in state 2 and had a larger number of state transitions. The NBS results showed that SHE patients had increased connectivity strength between networks. None of the properties was correlated with illness duration among patients with SHE. Conclusion: The patterns of dFC patterns may represent an adaptive and protective mode of the brain to deal with epileptic seizures. Abstract : After k‐means clustering, the SHE patients mainly have two dFC states. The frequency of state 1 was higher, which is characterized by stronger connections within the network, including executive control, default mode, sensorimotor, and visual network; state 2 occurred at a relatively low frequency, characterized by stronger connections between networks, including sensorimotor, visual, and auditory networks. It turns out that SHE patients showed preference in state 2.