A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma. Issue 14 (6th December 2022)

• Record Type: Journal Article
• Authors: Ardisson Korat, Andres V.; Chiu, Yu-Han; Bertrand, Kimberly A.; Zhang, Shumin; Epstein, Mara M.; Rosner, Bernard A.; Chiuve, Stephanie; Campos, Hannia; Giovannucci, Edward L.; Chavarro, Jorge E.; Birmann, Brenda M.
• Is Part Of: Leukemia & lymphoma. Volume 63:Issue 14(2022)
• Page Start: 3351
• Page End: 3361
• Publication Date: 2022-12-06
• Subjects: Red blood cell membrane fatty acids -- polyunsaturated fatty acids -- non-Hodgkin lymphoma -- epidemiology -- prospective -- etiology; Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.1080/10428194.2022.2131419
• Languages: English
• ISSNs: 1042-8194

Abstract

Abstract: Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses' Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; cis 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03–1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23–4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.