Antiretroviral Prophylaxis: A Digestive Complication to Know. Issue 12 (29th December 2021)

• Record Type: Journal Article
• Authors: Lemoine, Anaïs; Michot, Joëlle; Viala, Jérôme; Tounian, Patrick; Dollfus, Catherine
• Is Part Of: Pediatric emergency care. Volume 37:Issue 12(2021)
• Page Start: e1745
• Page End: e1746
• Publication Date: 2021-12-29
• Subjects: HIV -- postexposure prophylaxis -- antiretroviral prophylaxis; Pediatric emergencies -- Periodicals; 618.92002505
• DOI: 10.1097/PEC.0000000000001952
• Languages: English
• ISSNs: 0749-5161

Abstract

Abstract: An 8-year-old child experienced abdominal pain and melena due to duodenal and ileal ulcerations throughout antiretroviral prophylactic treatment after a needlestick injury. Mild to moderate adverse effects often occur with lamivudine and zidovudine, but more severe adverse effects such as intestinal ulcers resulting in melena after a prophylactic antiretroviral treatment may question the safety of the current guidelines.