Base‐Mediated N‐Acetylation of Anilines/Amines: Nitriles as a Surrogate of the Acetyl Group. Issue 1 (2nd January 2023)

• Record Type: Journal Article
• Authors: Kumar, Saurav; Agasti, Nityananda; Singh, Gajendra; Kumar, Anil
• Is Part Of: ChemistrySelect. Volume 8:Issue 1(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-02
• Subjects: Amines; Base-mediated -- N-acetylation -- transition-metal-free -- trifluoroacetylation; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202204679
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A base‐mediated protocol has been established for the N ‐acetylation of anilines/amines at room temperature. Reaction utilizes acetonitrile as a solvent as well as a surrogate of the acetyl group. Apart from acetonitrile, trifluoroacetonitrile could also be utilized in the reaction. The advantages of the reactions are simple operation, transition‐metal‐free approach, short reaction time, high functional group tolerance, and gram‐scale synthesis, which show the reaction's utility. The developed strategy represents a valuable approach in synthetic organic chemistry. Abstract : A base‐mediated N ‐acetylation of anilines/amines has been established. Reaction utilizes nitriles as a solvent as well as a surrogate of the acetyl group. The features of the reactions are a transition‐metal‐free approach and a short reaction time.