Atrial fibrillation detection using insertable cardiac monitor after stroke: A real‐world cohort study. (15th November 2022)

• Record Type: Journal Article
• Authors: Noubiap, Jean J.; Thomas, Gijo; Middeldorp, Melissa E.; Fitzgerald, John L.; Harper, Curtis; Sanders, Prashanthan
• Is Part Of: Journal of cardiovascular electrophysiology. Volume 34:Number 1(2023)
• Page Start: 142
• Page End: 146
• Publication Date: 2022-11-15
• Subjects: atrial fibrillation -- cryptogenic stroke -- implantable cardiac monitor -- internal loop recorder -- real‐world -- transient ischemic attack; Blood vessels -- Physiology -- Periodicals; Electrophysiology -- Periodicals; Heart -- Physiology -- Periodicals; 612.1
• DOI: 10.1111/jce.15744
• Languages: English
• ISSNs: 1045-3873

Abstract

Abstract: Objective: This study aimed to report the real‐world atrial fibrillation (AF) diagnostic yield of the implantable cardiac monitor (ICM) in patients with stroke or transient ischemic attack (TIA), and compare it to patients with an ICM for unexplained syncope. Methods: We used patient data from device clinics across the United States of America with ICM remote monitoring via PaceMate™, implanted for stroke or TIA, and unexplained syncope. Patients with known AF or atrial flutter were excluded. The outcome was AF lasting ≥2 min, adjudicated by International Board of Heart Rhythm Examiners certified cardiac device specialists. Results: We included a total of 2469 patients, 51.1% with stroke or TIA (mean age: 69.7 [SD: 12.2] years, 41.1% female) and 48.9% with syncope (mean age: 67.0 [SD: 17.1] years, 59.4% female). The cumulative AF detection rate in patients with stroke or TIA was 5.5%, 8.9%, and 14.0% at 12, 24, and 36 months, respectively. The median episode duration was 73 (interquartile range: 10–456) min, ranging from 2 min to 40.9 days, with 52.3%, 28.6%, and 4.4% of episodes lasting at least 1, 6, and 24 h, respectively. AF detection was increased by age (adjusted hazard ratio [for every 1‐year increase]: 1.024, 95% confidence interval: 1.008–1.040; p = .003), but was not influenced by sex ( p = .089). For comparison, the cumulative detection rate at 12, 24, and 36 months were, respectively, 2.4%, 5.2%, and 7.4% in patients with syncope. Conclusion: Patients with stroke or TIA have a higher rate of AF detection. However, this real‐world study shows significantly lower AF detection rates than what has been previously reported. Abstract : Atrial fibrillation (AF) detection yields in a real‐world cohort of patients with an implantable cardiac monitor. This study aimed to report the real‐world AF diagnostic yield of the implantable cardiac monitor in patients with stroke or transient ischemic attack undergoing remote monitoring in some device clinics across the United States of America. We observed a cumulative AF detection rate of 14% at 36 months, which is lower than that reported in the landmark cryptogenic stroke and underlying AF trial. The detection yield increased with age but did not differ between sexes.