Extraneural metastatic paediatric glioblastoma: Case report and literature review. (June 2020)

• Record Type: Journal Article
• Authors: Tan, Leanne Q.; Nagaputra, Jerry C.; Soh, Shui Yen; Ng, Lee Ping; Low, David C.Y.; Low, Sharon Y.Y.
• Is Part Of: Journal of clinical neuroscience. Volume 76(2020)
• Page Start: 246
• Page End: 248
• Publication Date: 2020-06
• Subjects: Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.04.004
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: Paediatric glioblastoma is uncommon and portends a grim prognosis. Extraneural metastasis in these tumours is rare and its underlying mechanisms are still unclear. The authors describe a unique case of pulmonary metastases from a glioblastoma in an adolescent. This case report is discussed in corroboration with current disease understanding. Abstract: The incidence of paediatric glioblastoma is uncommon in comparison to their adult counterpart. Even more infrequent are extraneural metastases in glioblastoma. A previously well 14-year-old female presented with progressive right hemiparesis secondary to a left fronto-temporal lobe glioblastoma (WHO IV). She underwent successful gross total resection for her brain tumour. Prior to commencement of her adjuvant treatment, she developed tumour recurrence associated with intra-lesional haemorrhage. Although she underwent a second surgery, the patient developed bilateral malignant pleural effusion secondary to extraneural pulmonary metastases. Early awareness of its existence enables prompt diagnosis for this devastating disease. The authors emphasize the urgent need for international collaborations to work together for children affected by this challenging brain tumour.