Heilaohuguosus A-S from the fruits of Kadsura coccinea and their hepatoprotective activity. (April 2021)

• Record Type: Journal Article
• Authors: Jia, Yan-Zhe; Yang, Yu-Pei; Cheng, Shao-Wu; Cao, Liang; Xie, Qing-Ling; Wang, Meng-Yun; Li, Bin; Jian, Yu-Qing; Liu, Bin; Peng, Cai-Yun; Wang, Wei
• Is Part Of: Phytochemistry. Volume 184(2021)
• Publication Date: 2021-04
• Subjects: Kadsura coccinea (Lem.) A. C. Sm. -- Schisandraceae -- Heilaohu -- Phytochemical -- Lignans -- Hepatoprotective activity -- Fruit; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2021.112678
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Phytochemical investigations on the fresh fruits of Kadsura coccinea (Lem.) A. C. Sm. have led to the isolation of fourteen undescribed 2, 2′-cyclolignans named heilaohuguosus A-N, four undescribed aryltetrahydronaphthalene lignans, heilaohuguosus O-R and one tetrahydrofuran lignan, heilaohuguosu S, with twenty-seven previously described lignan analogues. Their structures and absolute configurations of heilaohuguosus A-S were established by spectroscopic methods including 1D and 2D-NMR techniques and CD experiments. All isolated compounds were evaluated for their hepatoprotective activity against APAP-induced toxicity in HepG-2 cells, four 2, 2′-cyclolignans, heilaohuguosus A and L, tiegusanin I and kadsuphilol I showed good hepatoprotective activities against APAP toxicity in HepG-2 cells with cell survival rates of 53.5 ± 1.7%, 55.2 ± 1.2%, 52.5 ± 2.4%, and 54.0 ± 2.2% (positive control bicyclol, 52.1 ± 1.3%) at 10 μ M, respectively. Graphical abstract: Image 1 Highlights: Nineteen undescribed lignans were isolated from fruits of K. coccinea . This is the first phytochemistry study on the fruits of K. coccinea Four compounds showed good hepatoprotective activities better than positive control bicyclol