Age-specific trends and outcomes of hospitalizations with acute heart failure in the United States. (1st May 2021)

• Record Type: Journal Article
• Authors: Elbadawi, Ayman; Dang, Alexander; Elgendy, Islam Y.; Thakker, Ravi; Albaeni, Aiham; Omer, Mohamed A.; Mohamed, Ahmed H.; Gilani, Syed; Chatila, Khaled; Khalife, Wissam I.; Almustafa, Ahmed
• Is Part Of: International journal of cardiology. Volume 330(2021)
• Page Start: 98
• Page End: 105
• Publication Date: 2021-05-01
• Subjects: Acute heart failure -- Age-specific changes -- Mortality -- Readmissions; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2021.02.031
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Objective: To analyze the age-specific temporal trends, in-hospital outcomes and readmissions for acute heart failure (HF). Background: There is a paucity of data on the age-specific differences in the trends and outcomes of hospitalizations with acute HF. Methods: The National Inpatients Sample database years 2002–2016 and the National Readmissions Database years 2013–2016 were used to identify primary hospitalizations for acute HF. We analyzed the age-specific temporal trends, in-hospital outcomes, and readmissions for acute HF. Results: The annual rate of hospitalizations for acute HF declined from 456 per 100, 000 people in 2002 to 356 per 100, 000 people in 2016 (Ptrend < 0.001). The decline was observed among all age groups, except those aged 18–44 years. There was a decline in in-hospital mortality among all age groups, except for those aged 18–34 years. Compared with 18–34 years, adjusted in-hospital mortality was lower among 35–44 years (odds ratio 0.78, 95% confidence interval [CI] 0.74–0.82) and 45–54 years (OR 0.87; 95% CI 0.83–0.91) but higher among 55–64 years (OR 1.60; 95% CI 1.54–1.67) and ≥ 75 year (OR 2.54; 95% CI 2.44–2.64). Compared with 18–34 years, 30-day HF-related readmissions were significantly lower in older age groups (>34 years). Conclusions: This nationwide contemporary analysis demonstrated a decline in the annual rates of hospitalizations with acute HF across all age categories except those aged 18–44 years. There was a reduction in rates of in-hospital mortality among middle-aged and older patients, but not in those aged 18–34. In-hospital mortality exhibited a dichotomous relationship with age. There was an inverse relationship between age and 30-days HF readmissions. Highlights: The frequency and in-hospital mortality of acute HF hospitalizations declined among all age groups, except younger patients. In-hospital mortality exhibited a dichotomous relationship with age. There was an inverse relationship between age and 30-days HF readmissions. Future studies are warranted to explore primary and secondary preventive measures for younger patients with acute HF.