Aerobic exercise and inspiratory muscle training increase functional capacity in patients with univentricular physiology after Fontan operation: A randomized controlled trial. (1st May 2021)

• Record Type: Journal Article
• Authors: Turquetto, Aida Luiza Ribeiro; dos Santos, Marcelo Rodrigues; Agostinho, Daniela Regina; Sayegh, Ana Luiza Carrari; de Souza, Francis Ribeiro; Amato, Luciana Patrick; Barnabe, Milena Schiezari Ru; de Oliveira, Patrícia Alves; Liberato, Gabriela; Binotto, Maria Angélica; Negrão, Carlos Eduardo; Canêo, Luiz Fernando; Trindade, Evelinda; Jatene, Fabio Biscegli; Jatene, Marcelo Biscegli
• Is Part Of: International journal of cardiology. Volume 330(2021)
• Page Start: 50
• Page End: 58
• Publication Date: 2021-05-01
• Subjects: Fontan procedure -- Aerobic exercise -- Inspiratory muscle training -- Functional capacity -- Autonomic control -- Pulmonary function; Cardiology -- Periodicals; Electronic journals; 616.12
• DOI: 10.1016/j.ijcard.2021.01.058
• Languages: English
• ISSNs: 0167-5273

Abstract

Abstract: Background: The effect of exercise training and its mechanisms on the functional capacity improvement in Fontan patients (FP) are virtually unknown. This trial evaluated four-month aerobic exercise training and inspiratory muscle training on functional capacity, pulmonary function, and autonomic control in patients after Fontan operation. Methods: A randomized controlled clinical trial with 42 FP aged 12 to 30 years and, at least, five years of Fontan completion. Twenty-seven were referred to a four-months supervised and personalized aerobic exercise training (AET) or an inspiratory muscle training (IMT). A group of non-exercise (NET) was used as control. The effects of the exercise training in peak VO2 ; pulmonary volumes and capacities, maximal inspiratory pressure (MIP); muscle sympathetic nerve activity (MSNA); forearm blood flow (FBF); handgrip strength and cross-sectional area of the thigh were analyzed. Results: The AET decreased MSNA ( p = 0.042), increased FBF ( p = 0.012) and handgrip strength ( p = 0.017). No significant changes in autonomic control were found in IMT and NET groups. Both AET and IMT increased peak VO2, but the increase was higher in the AET group compared to IMT (23% vs. 9%). No difference was found in the NET group. IMT group showed a 58% increase in MIP ( p = 0.008) in forced vital capacity ( p = 0.011) and forced expiratory volume in the first second (p = 0.011). No difference in pulmonary function was found in the AET group. Conclusions: Both aerobic exercise and inspiratory muscle training improved functional capacity. The AET group developed autonomic control, and handgrip strength, and the IMT increased inspiratory muscle strength and spirometry. Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT02283255 Graphical abstract: Unlabelled Image Highlights: Aerobic exercise and inspiratory muscle training improve functional capacity in Fontan patients The mechanisms involved on each training are different Aerobic exercise training improves autonomic control and skeletal muscle strength Inspiratory muscle training improves inspiratory muscle strength and spirometry Higher peak VO2 occurred in patients who performed the aerobic exercise training