Role of microRNA and long non-coding RNA in Marek's disease tumorigenesis in chicken. (March 2021)

• Record Type: Journal Article
• Authors: Zhang, Zhaobo; Zhang, Sishi; Wang, Guoshuai; Feng, Siyu; Han, Kexin; Han, Limei; Han, Liping
• Is Part Of: Research in veterinary science. Volume 135(2021)
• Page Start: 134
• Page End: 142
• Publication Date: 2021-03
• Subjects: Non-coding RNA -- microRNA -- Long non-coding RNA -- Tumorigenesis -- Marek's disease virus -- Chicken; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Médecine vétérinaire -- Recherche -- Périodiques; Diergeneeskunde; 636.089
• DOI: 10.1016/j.rvsc.2021.01.007
• Languages: English
• ISSNs: 0034-5288

Abstract

Abstract: Marek's disease virus (MDV), the causative agent of Marek's disease (MD), results in highly infectious phymatosis, lymphatic tissue hyperplasia, and neoplasia. MD is associated with high morbidity and mortality rate. Non-coding RNAs (ncRNAs) entails long non-coding RNA (lncRNA) and microRNA (miRNA). Numerous studies have reported that specific miRNAs and lncRNAs participate in multiple cellular processes, such as proliferation, migration, and tumor cell invasion. Specialized miRNAs and lncRNAs militate a similar role in MD tumor oncogenesis. Despite its growing popularity, only a few reviews are available on ncRNA in MDV tumor oncogenes. Herein, we summarized the role of the miRNAs and lncRNAs in MD tumorigenesis. Altogether, we brought forth the research issues, such as MD prevention, screening, regulatory network formation, novel miRNAs, and lncRNAs analysis in MD that needs to be explored further. This review provides a theoretical platform for the further analysis of miRNAs and lncRNAs functions and the prevention and control of MD and malignancies in domestic animals. Highlights: Overview the virulence evolution and worldwide hazard of MD. Summarize the current microRNAs and long non-coding RNAs literature that can act regulatory role in MD tumorigenesis. Forming regulating pathways in microRNAs, long non-coding RNAs and MD tumorigenesis. Prospecting the research focus in MD tumorigenesis and non-coding RNAs.