A practical method for N-alkylation of phosphinic (thio)amides with alcohols via transfer hydrogenation. Issue 24 (14th June 2019)

• Record Type: Journal Article
• Authors: Jankins, Tanner C.; Qin, Zi-Yang; Engle, Keary M.
• Is Part Of: Tetrahedron. Volume 75:Issue 24(2019)
• Page Start: 3272
• Page End: 3281
• Publication Date: 2019-06-14
• Subjects: Transfer hydrogenation -- Ruthenium -- Phosphorous -- Phosphinic amide -- Amination; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2019.04.029
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: This manuscript describes a modular method for preparing N -alkyl phosphinic amides from primary or secondary alcohols and primary phosphinic amide (R 1 R 2 P = ONH2 ) nucleophiles via transfer hydrogenation. The transformation typically proceeds in excellent yields, employs conveniently available reagents, and produces water as the only byproduct. Graphical abstract: Image 1