Chemogenetics: Beyond Lesions and Electrodes. Issue 2 (29th April 2021)

• Record Type: Journal Article
• Authors: Poth, Kelly M; Texakalidis, Pavlos; Boulis, Nicholas M
• Is Part Of: Neurosurgery. Volume 89:Issue 2(2021)
• Page Start: 185
• Page End: 195
• Publication Date: 2021-04-29
• Subjects: Chemogenetics -- Chemogenetic neuromodulation -- Designer receptor activated by designer drugs (DREADD) -- Translational medicine -- Viral vector; Nervous system -- Surgery -- Periodicals; 617.48005
• DOI: 10.1093/neuros/nyab147
• Languages: English
• ISSNs: 0148-396X

Abstract

Abstract: The field of chemogenetics has rapidly expanded over the last decade, and engineered receptors are currently utilized in the lab to better understand molecular interactions in the nervous system. We propose that chemogenetic receptors can be used for far more than investigational purposes. The potential benefit of adding chemogenetic neuromodulation to the current neurosurgical toolkit is substantial. There are several conditions currently treated surgically, electrically, and pharmacologically in clinic, and this review highlights how chemogenetic neuromodulation could improve patient outcomes over current neurosurgical techniques. We aim to emphasize the need to take these techniques from bench to bedside.