Anatomic thermochromic tissue-mimicking phantom of the lumbar spine for pre-clinical evaluation of MR-guided focused ultrasound (MRgFUS) ablation of the facet joint. (1st January 2021)

• Record Type: Journal Article
• Authors: Zhang, Wendy; Trivedi, Hari; Adams, Matthew; Losey, Aaron D.; Diederich, Chris J.; Ozhinsky, Eugene; Rieke, Viola; Bucknor, Matthew D.
• Is Part Of: International journal of hyperthermia. Volume 38:Number 1(2021)
• Page Start: 130
• Page End: 135
• Publication Date: 2021-01-01
• Subjects: Chronic low back pain (LBP) -- MRI-guided focused ultrasound surgery (MRgFUS) -- thermochromic tissue-mimicking phantom (TTMP) -- 3D-printed model -- pre-clinical evaluation; Thermotherapy -- Periodicals; 615.832
• DOI: 10.1080/02656736.2021.1880650
• Languages: English
• ISSNs: 0265-6736

Abstract

Abstract: Objective: To develop a thermochromic tissue-mimicking phantom (TTMP) with an embedded 3D-printed bone mimic of the lumbar spine to evaluate MRgFUS ablation of the facet joint and medial branch nerve. Materials and methods: Multiple 3D-printed materials were selected and characterized by measurements of speed of sound and linear acoustic attenuation coefficient using a through-transmission technique. A 3D model of the lumbar spine was segmented from a de-identified CT scan, and 3D printed. The 3D-printed spine was embedded within a TTMP with thermochromic ink color change setpoint at 60 °C. Multiple high energy sonications were targeted to the facet joints and medial branch nerve anatomical location using an ExAblate MRgFUS system connected to a 3T MR scanner. The phantom was dissected to assess sonication targets and the surrounding structures for color change as compared to the expected region of ablation on MR-thermometry. Results: The measured sound attenuation coefficient and speed of sound of gypsum was 240 Np/m-MHz and 2471 m/s, which is the closest to published values for cortical bone. Following sonication, dissection of the TTMP revealed good concordance between the regions of color change within the phantom and expected areas of ablation on MR-thermometry. No heat deposition was observed in critical areas, including the spinal canal and nerve roots from either color change or MRI. Conclusion: Ablated regions in the TTMP correlated well with expected ablations based on MR-thermometry. These findings demonstrate the utility of an anatomic spine phantom in evaluating MRgFUS sonication for facet joint and medial branch nerve ablations.