Clinicopathological significance of neutrophil-rich colorectal carcinoma. Issue 1 (26th July 2021)

• Record Type: Journal Article
• Authors: Rottmann, Bruce G; Patel, Natalie; Ahmed, Muhammad; Deng, Yanhong; Ciarleglio, Maria; Vyas, Monika; Jain, Dhanpat; Zhang, Xuchen
• Is Part Of: Journal of clinical pathology. Volume 76:Issue 1(2023)
• Page Start: 34
• Page End: 39
• Publication Date: 2021-07-26
• Subjects: colorectal neoplasms -- pathology -- surgical -- rectal neoplasms -- gastrointestinal neoplasms; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jclinpath-2021-207702
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Aims: The importance of the interaction between tumour cells and neutrophils has recently begun to emerge. However, the significance of tumour-infiltrating neutrophil (TIN) in colorectal carcinomas (CRCs) remains unclear. The aim of this study was to investigate the prognostic significance of TIN in CRCs. Methods: CRCs were evaluated for TIN and were classified as neutrophil-rich (NR), neutrophil-intermediate (NI) and neutrophil-poor (NP) based on the presence of >15, 5–15 and <5 TIN per 100 tumour cells, respectively. Various clinicopathological parameters were recorded in each case including age, gender, histological grade, tumour, node, metastasis (TNM) stage, tumour location and DNA mismatch repair (MMR) status. Results: Among the 348 CRC cases reviewed, 38 cases were NR, 43 cases were NI and 267 cases were NP. High TIN was associated with higher histological grade (p=0.0222), right-sided tumour location (p=0.0025), advanced TNM stage (p=0.0346) and higher rate of MMR-deficient CRCs (p=0.0027). Patients with NR CRCs had significantly poorer 5-year recurrence-free survival comparing to patients with NI or NP CRCs on Kaplan-Meier analysis (p=0.0001) and high TIN remained an independent risk factor with multivariate analysis (p=0.0137; HR: 1.930, 95% CI: 1.144 to 3.255). NR CRCs are more commonly seen in MMR-deficient than in MMR-proficient CRCs (p=0.0006). Patients with MMR-deficient NR CRCs showed similar 5-year recurrence-free survival compared with MMR-proficient NR CRCs. Conclusions: Our findings reveal that high TIN confers poorer patient prognosis in both MMR-proficient and MMR-deficient CRCs.