Nanoemulsions as novel nanocarrieres for drug delivery across the skin: In-vitro, in-vivo evaluation of miconazole nanoemulsions for treatment of Candidiasis albicans. Issue 1 (1st January 2021)

• Record Type: Journal Article
• Authors: Farooq, Umar; Rasul, Akhtar; Zafarullah, Muhammad; Abbas, Ghulam; Rasool, Maria; Ali, Farman; Ahmed, Shabbir; Javaid, Zeeshan; Abid, Zoya; Riaz, Humayun; Mahmood Arshad, Rana Khalid; Maryam, Shayan; Amna, Naseem; Asif, Kanwal
• Is Part Of: Designed monomers and polymers. Volume 24:Issue 1(2021)
• Page Start: 240
• Page End: 258
• Publication Date: 2021-01-01
• Subjects: Nanoemulsion -- gelatin -- miconazole -- topical delivery system; Monomers -- Periodicals; Polymers -- Periodicals; Macromolecules -- Periodicals; Polymerization -- Periodicals; 547.7005
• DOI: 10.1080/15685551.2021.1965724
• Languages: English
• ISSNs: 1385-772X

Abstract

ABSTRACT: In the current research, attempt is made to fabricate a nanoemulsion (NE) containing an antifungal agent. The prepared formulation has been expected to enhance skin penetration. It is also studied for in vitro drug release and toxicity assessment. Spontaneous titration method was used for preparation of NE. Prepared NE were characterized for their charge, size, morphology, rheological behaviour, drug release profile, skin permeability. The drug permeation and skin irritation were investigated. The in vitro antifungal activity was inspected using the well agar diffusion method. Miconazole NE showed good penetration in the skin as compared to marketed products. SEM showed semispherical shapes of the droplets. Zeta potential and zeta sizer showed that size was in nano ranges having positive charge.