Is there a link between plasma progesterone 1–2 days before frozen embryo transfers (FET) and ART outcomes in frozen blastocyst transfers?. (3rd July 2021)

• Record Type: Journal Article
• Authors: Ramos, Natalia N.; Pirtea, Paul; Benammar, Achraf; Ziegler, Dominique de; Jolly, Emilie; Frydman, Rene; Poulain, Marine; Ayoubi, Jean Marc
• Is Part Of: Gynecological endocrinology. Volume 37:Number 7(2021)
• Page Start: 614
• Page End: 617
• Publication Date: 2021-07-03
• Subjects: Luteal-phase support -- frozen embryo transfer -- progesterone -- clinical pregnancy rate -- assisted reproductive technology; Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.1080/09513590.2020.1825669
• Languages: English
• ISSNs: 0951-3590

Abstract

Abstract: Objective: To study the efficacy of combined administration of subcutaneous and vaginal progesterone for priming frozen blastocysts transfers, looking at progesterone levels and ART outcome. Design: Retrospective study. Setting patients: Three hundred and twenty frozen blastocyst transfer cycles conducted in 213 women aged up to 42 years, BMI between 18 and 30 kg/m 2, with anatomically normal uterus who underwent frozen embryo transfers (FETs) from February 2019 to December 2019 with a combined luteal-phase support (LPS) associating subcutaneous and vaginal progesterone. Patients with recurrent pregnancy loss (RPL) were excluded. Results: When using combined vaginal and subcutaneous LPS, SPL >10.50 ng/mL in 95% of cases, with a minimum value of 7.02 ng/mL. CPR, OPR, and global miscarriage rates were 38.4%, 30.9%, and 19.5%, respectively. Analyzing results per quartiles, revealed that miscarriage rates were significantly inferior, and IR were higher in the upper two quartiles of serum progesterone (>21.95 ng/mL) on the day before FET, while there was no difference in CPR and OPR. Conclusions: We report ART outcome of frozen blastocyst transfers performed using a combination of vaginal and subcutaneous progesterone for LPS. ART results were honorable and SPL favorable 1–2 days before FET in 99% of cases.