Identification of 16, 25-O-diacetyl-cucurbitane F and 25-O-acetyl-23, 24-dihydrocucurbitacin F as novel anti-cancer chemicals. Issue 8 (15th August 2018) - Wang, Wenxue
Abstract : Seven new cucurbitane glucosides, hemslepensides J-P (1 –7 ), and two known compounds, 16, 25- O -diacetyl-cucurbitane F (8 ) and 25- O -acetyl-23, 24-dihydrocucurbitacin F (9 ), were isolated from the tubers of Hemsleya pengxianensis var. jinfushanensis . The structures of 1 –7 were elucidated using infrared absorption spectroscopy, nuclear magnetic resonance spectroscopy and high-resolution electrospray ionization mass spectrometry. The treatment of HT29 cells, human colon cancer cells, with compounds 8 and 9 inhibited cell proliferation. Further study demonstrated that compounds 8 and 9 induced F-actin aggregation, G2 /M phase cell cycle arrest and cell apoptosis in HT29 cells. In summary, the present study enriched the chemical composition research of H. pengxianensis, and suggested that the compounds 8 /9 treatment may be a potentially useful therapeutic option for colon cancer.