'High vault-age': non-coding RNA control of autophagy. Issue 2 (19th February 2020)

• Record Type: Journal Article
• Authors: Büscher, Magdalena; Horos, Rastislav; Hentze, Matthias W.
• Is Part Of: Open biology. Volume 10:Issue 2(2020)
• Publication Date: 2020-02-19
• Subjects: p62 -- riboregulation -- vault RNA 1-1; Biology -- Periodicals; 570
• DOI: 10.1098/rsob.190307
• Languages: English
• ISSNs: 2046-2441

Abstract

Abstract : Abstract : RNA-binding proteins typically change the fate of RNA, such as stability, translation or processing. Conversely, we recently uncovered that the small non-coding vault RNA 1-1 (vtRNA1-1) directly binds to the autophagic receptor p62/SQSTM1 and changes the protein's function. We refer to this process as 'riboregulation'. Here, we discuss this newly uncovered vault RNA function against the background of three decades of vault RNA research. We highlight the vtRNA1-1-p62 interaction as an example of riboregulation of a key cellular process.