Identification of potent chromone embedded [1, 2, 3]-triazoles as novel anti-tubercular agents. Issue 4 (4th April 2018)

• Record Type: Journal Article
• Authors: Nalla, Viswanadh; Shaikh, Aslam; Bapat, Sanket; Vyas, Renu; Karthikeyan, M.; Yogeeswari, P.; Sriram, D.; Muthukrishnan, M.
• Is Part Of: Royal Society open science. Volume 5:Issue 4(2018)
• Publication Date: 2018-04-04
• Subjects: chromone -- triazole -- molecular docking -- anti-mycobacterial activity; Science -- Periodicals; 500
• DOI: 10.1098/rsos.171750
• Languages: English
• ISSNs: 2054-5703

Abstract

Abstract : A series of 20 novel chromone embedded [1, 2, 3]-triazoles derivatives were synthesized via an easy and convenient synthetic procedure starting from 2-hydroxy acetophenone. The in vitro anti-mycobacterial evaluation studies carried out in this work reveal that seven compounds exhibit significant inhibition against Mycobacterium tuberculosis H37Rv strain with MIC in the range of 1.56–12.5 µg ml −1 . Noticeably, compound 6s was the most potent compound in vitro with a MIC value of 1.56 µg ml −1 . Molecular docking and chemoinformatics studies revealed that compound 6s displayed drug-like properties against the enoyl-acyl carrier protein reductase of M. tuberculosis further establishing its potential as a potent inhibitor.