Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes. Issue 2 (14th February 2018)

• Record Type: Journal Article
• Authors: Miyazawa, Taiki; Kamiyoshihara, Reina; Shimizu, Naoki; Harigae, Takahiro; Otoki, Yurika; Ito, Junya; Kato, Shunji; Miyazawa, Teruo; Nakagawa, Kiyotaka
• Is Part Of: Royal Society open science. Volume 5:Issue 2(2018)
• Publication Date: 2018-02-14
• Subjects: Amadori-glycated phosphatidylethanolamine -- curcumin -- glucose transporter -- glycolipid -- liposome -- Maillard reaction product; Science -- Periodicals; 500
• DOI: 10.1098/rsos.171249
• Languages: English
• ISSNs: 2054-5703

Abstract

Abstract : Liposomes consisting of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.