Drought and immunity determine the intensity of West Nile virus epidemics and climate change impacts. Issue 1848 (8th February 2017)

• Record Type: Journal Article
• Authors: Paull, Sara H.; Horton, Daniel E.; Ashfaq, Moetasim; Rastogi, Deeksha; Kramer, Laura D.; Diffenbaugh, Noah S.; Kilpatrick, A. Marm
• Is Part Of: Proceedings. Volume 284:Issue 1848(2017)
• Publication Date: 2017-02-08
• Subjects: vector-borne disease -- nonlinear temperature–disease relationship -- Culex -- disease ecology -- global warming; Biology -- Periodicals; 570.5
• DOI: 10.1098/rspb.2016.2078
• Languages: English
• ISSNs: 0962-8452

Abstract

Abstract : The effect of global climate change on infectious disease remains hotly debated because multiple extrinsic and intrinsic drivers interact to influence transmission dynamics in nonlinear ways. The dominant drivers of widespread pathogens, like West Nile virus, can be challenging to identify due to regional variability in vector and host ecology, with past studies producing disparate findings. Here, we used analyses at national and state scales to examine a suite of climatic and intrinsic drivers of continental-scale West Nile virus epidemics, including an empirically derived mechanistic relationship between temperature and transmission potential that accounts for spatial variability in vectors. We found that drought was the primary climatic driver of increased West Nile virus epidemics, rather than within-season or winter temperatures, or precipitation independently. Local-scale data from one region suggested drought increased epidemics via changes in mosquito infection prevalence rather than mosquito abundance. In addition, human acquired immunity following regional epidemics limited subsequent transmission in many states. We show that over the next 30 years, increased drought severity from climate change could triple West Nile virus cases, but only in regions with low human immunity. These results illustrate how changes in drought severity can alter the transmission dynamics of vector-borne diseases.