The 'allosteron' model for entropic allostery of self-assembly. (19th June 2018)

• Record Type: Journal Article
• Authors: McLeish, Tom; Schaefer, C.; von der Heydt, A. C.
• Is Part Of: Philosophical transactions. Volume 373:Number 1749(2018)
• Publication Date: 2018-06-19
• Subjects: allostery -- self-assembly -- ligand-binding; Biology -- Periodicals; Science -- Periodicals; 570
• DOI: 10.1098/rstb.2017.0186
• Languages: English
• ISSNs: 0962-8436

Abstract

Abstract : Using the simple 'allosteron' model, we show that it is possible, in principle, to elicit pathways by which fluctuation allostery affects self-assembly of protein complexes. We treat the cases of (i) protein fibrils and nucleation, (ii) n -mer protein complexes, and (iii) weakly attractive allosteric interactions in protein-like soft nanoscale objects that can be tuned to define exclusive self-associating families. This article is part of a discussion meeting issue 'Allostery and molecular machines'.