Multi-modality cerebral aneurysm haemodynamic analysis: in vivo 4D flow MRI, in vitro volumetric particle velocimetry and in silico computational fluid dynamics. Issue 158 (27th September 2019)

• Record Type: Journal Article
• Authors: Brindise, Melissa C.; Rothenberger, Sean; Dickerhoff, Benjamin; Schnell, Susanne; Markl, Michael; Saloner, David; Rayz, Vitaliy L.; Vlachos, Pavlos P.
• Is Part Of: Journal of the Royal Society interface. Volume 16:Issue 158(2019)
• Publication Date: 2019-09-27
• Subjects: cerebral aneurysm -- particle image velocimetry -- 4D flow MRI -- wall shear stress -- oscillatory shear index -- relative residence time; Physical sciences -- Research -- Periodicals; Life sciences -- Research -- Periodicals; Interdisciplinary research -- Periodicals; 570.5
• DOI: 10.1098/rsif.2019.0465
• Languages: English
• ISSNs: 1742-5689

Abstract

Abstract : Typical approaches to patient-specific haemodynamic studies of cerebral aneurysms use image-based computational fluid dynamics (CFD) and seek to statistically correlate parameters such as wall shear stress (WSS) and oscillatory shear index (OSI) to risk of growth and rupture. However, such studies have reported contradictory results, emphasizing the need for in-depth multi-modality haemodynamic metric evaluation. In this work, we used in vivo 4D flow MRI data to inform in vitro particle velocimetry and CFD modalities in two patient-specific cerebral aneurysm models (basilar tip and internal carotid artery). Pulsatile volumetric particle velocimetry experiments were conducted, and the particle images were processed using Shake-the-Box, a particle tracking method. Distributions of normalized WSS and relative residence time were shown to be highly yet inconsistently affected by minor flow field and spatial resolution variations across modalities, and specific relationships among these should be explored in future work. Conversely, OSI, a non-dimensional parameter, was shown to be more robust to the varying assumptions, limitations and spatial resolutions of each subject and modality. These results suggest a need for further multi-modality analysis as well as development of non-dimensional haemodynamic parameters and correlation of such metrics to aneurysm risk of growth and rupture.