There is no 'Conundrum' of InsP6. Issue 11 (November 2015)

• Record Type: Journal Article
• Authors: Irvine, Robin F.; Bulley, Simon J.; Wilson, Miranda S.; Saiardi, Adolfo
• Is Part Of: Open biology. Volume 5:Issue 11(2015)
• Publication Date: 2015-11
• Subjects: Biology -- Periodicals; 570
• DOI: 10.1098/rsob.150181
• Languages: English
• ISSNs: 2046-2441

Abstract

Abstract : Indirect assays have claimed to quantify phytate (InsP6 ) levels in human biofluids, but these have been based on the initial assumption that InsP6 is there, an assumption that our more direct assays disprove. We have shown that InsP6 does not and cannot (because of the presence of an active InsP6 phosphatase in serum) exist in mammalian serum or urine. Therefore, any physiological effects of dietary InsP6 can only be due either to its actions in the gut as a polyvalent cation chelator, or to inositol generated by its dephosphorylation by gut microflora.