A novel and highly efficient esterification process using triphenylphosphine oxide with oxalyl chloride. Issue 2 (21st February 2018)

• Record Type: Journal Article
• Authors: Jia, Mingzhu; Jiang, Lixue; Niu, Fanfan; Zhang, Yu; Sun, Xiaoling
• Is Part Of: Royal Society open science. Volume 5:Issue 2(2018)
• Publication Date: 2018-02-21
• Subjects: triphenylphosphine oxide -- coupling reagent -- oxalyl chloride -- esterification; Science -- Periodicals; 500
• DOI: 10.1098/rsos.171988
• Languages: English
• ISSNs: 2054-5703

Abstract

Abstract : Triphenylphosphine oxide (TPPO) and oxalyl chloride ((COCl)2 ) are used as novel and high-efficiency coupling reagents for the esterification of alcohols with carboxylic acids via the TPPO/(COCl)2 system at room temperature for 1 h. The reaction represents the first TPPO-promoted esterification under mild and neutral conditions with excellent yields. Furthermore, we proposed a plausible mechanism with the help of 31 P NMR spectroscopy.