Homeostatic plasticity mechanisms in mouse V1. (5th March 2017)

• Record Type: Journal Article
• Authors: Kaneko, Megumi; Stryker, Michael P.
• Is Part Of: Philosophical transactions. Volume 372:Number 1715(2017)
• Publication Date: 2017-03-05
• Subjects: cortical plasticity -- visual cortex -- critical period -- mouse V1 -- homeostatic -- TNFα; Biology -- Periodicals; Science -- Periodicals; 570
• DOI: 10.1098/rstb.2016.0504
• Languages: English
• ISSNs: 0962-8436

Abstract

Abstract : Mechanisms thought of as homeostatic must exist to maintain neuronal activity in the brain within the dynamic range in which neurons can signal. Several distinct mechanisms have been demonstrated experimentally. Three mechanisms that act to restore levels of activity in the primary visual cortex of mice after occlusion and restoration of vision in one eye, which give rise to the phenomenon of ocular dominance plasticity, are discussed. The existence of different mechanisms raises the issue of how these mechanisms operate together to converge on the same set points of activity. This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.