Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the model drug curcumin. Issue 10 (17th October 2018)

• Record Type: Journal Article
• Authors: Cardoso, Beatriz D.; Rio, Irina S. R.; Rodrigues, Ana Rita O.; Fernandes, Francisca C. T.; Almeida, B. G.; Pires, A.; Pereira, A. M.; Araújo, J. P.; Castanheira, Elisabete M. S.; Coutinho, Paulo J. G.
• Is Part Of: Royal Society open science. Volume 5:Issue 10(2018)
• Publication Date: 2018-10-17
• Subjects: magnesium ferrite nanoparticles -- magnetoliposomes -- curcumin -- superparamagnetism -- pegylation -- cancer therapy; Science -- Periodicals; 500
• DOI: 10.1098/rsos.181017
• Languages: English
• ISSNs: 2054-5703

Abstract

Abstract : Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behaviour, with a maximum magnetization of 16.2 emu g −1, a coercive field of 22.1 Oe and a blocking temperature of 183.2 K. These MgFe2 O4 nanoparticles were used to produce aqueous and solid magnetoliposomes, with sizes below 130 nm. The potential drug curcumin was successfully incorporated in these nanosystems, with high encapsulation efficiencies (above 89%). Interaction by fusion between both types of drug-loaded magnetoliposomes (with or without PEGylation) and models of biological membranes was demonstrated, using FRET or fluorescence quenching assays. These results point to future applications of magnetoliposomes containing MgFe2 O4 nanoparticles in cancer therapy, allowing combined magnetic hyperthermia and chemotherapy.