Attenuated monoamine oxidase a impairs endometrial receptivity in women with adenomyosis via downregulation of FOXO1. Issue 6 (27th September 2021)

• Record Type: Journal Article
• Authors: Tian, Jiao; Zhang, Chunxue; Kang, Nannan; Wang, Junxia; Kong, Na; Zhou, Jidong; Wu, Min; Ding, Lijun; Sun, Haixiang; Yan, Guijun; Sheng, Xiaoqiang
• Is Part Of: Biology of reproduction. Volume 105:Issue 6(2021)
• Page Start: 1443
• Page End: 1457
• Publication Date: 2021-09-27
• Subjects: monoamine oxidase A -- endometrial receptivity -- adenomyosis -- endometrial epithelial cells -- proliferation; Reproduction -- Periodicals; Biology; Reproduction; Reproduction; Electronic journals; Periodicals; Periodicals; 571.805
• DOI: 10.1093/biolre/ioab182
• Languages: English
• ISSNs: 0006-3363

Abstract

Abstract: The establishment of endometrial receptivity is a prerequisite for successful pregnancy. Women with adenomyosis possess a lower chance of clinical pregnancy after assisted reproductive technology, which is partially due to impaired endometrial receptivity. The establishment of endometrial receptivity requires the participation of multiple processes, and proper endometrial epithelial cell (EEC) proliferation is indispensable. Monoamine oxidase A (MAOA) is a key molecule that regulates neurotransmitter metabolism in the nervous system. In the present study, we demonstrated a novel role for MAOA in the establishment of endometrial receptivity in women with adenomyosis and in an adenomyotic mouse model. Attenuated MAOA impairs endometrial receptivity by promoting inappropriate proliferation of EECs via the downregulation of FOXO1 during the window of implantation. These results revealed that MAOA plays a vital role in endometrial receptivity in female reproduction. Abstract : Collectively, our data allowed us to identify a vital role for MAOA in the maintenance of endometrial receptivity in women with adenomyosis via downregulation of FOXO1. Graphical Abstract: