Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019. (28th September 2020)

• Record Type: Journal Article
• Authors: Martinot, Martin; Jary, Aude; Fafi-Kremer, Samira; Leducq, Valentin; Delagreverie, Heloise; Garnier, Marc; Pacanowski, Jérôme; Mékinian, Arsène; Pirenne, France; Tiberghien, Pierre; Calvez, Vincent; Humbrecht, Catherine; Marcelin, Anne-Geneviève; Lacombe, Karine
• Is Part Of: Clinical infectious diseases. Volume 73:Number 7(2021)
• Page Start: e1762
• Page End: e1765
• Publication Date: 2020-09-28
• Subjects: SARS-CoV-2 -- remdesivir -- RNA-dependent RNA-polymerase mutation -- COVID-19 -- convalescent plasma; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciaa1474
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma.