Switching From Ceftriaxone to Cefotaxime Significantly Contributes to Reducing the Burden of Clostridioides difficile infections. (23rd August 2020)

• Record Type: Journal Article
• Authors: Wendt, Sebastian; Ranft, Donald; Rodloff, Arne C; Lippmann, Norman; Lübbert, Christoph
• Is Part Of: Open forum infectious diseases. Volume 7:Number 9(2020)
• Publication Date: 2020-08-23
• Subjects: antimicrobial stewardship -- cephalosporines -- biliary excretion -- Clostridioides difficile -- PK/PD; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa312
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We analyzed Clostridioides difficile infection (CDI) rates and various antimicrobials' application densities from 2013 to 2019 at Leipzig University Hospital, Germany, by using multivariate linear regression. Ceftriaxone application was the only independent predictor of CDI incidence. Thus, antibiotics' specific pharmacokinetic and pharmacodynamic properties such as biliary excretion of ceftriaxone in its active form should be considered when determining their potential to cause CDI.