Occult Talaromyces marneffei Infection Unveiled by the Novel Mp1p Antigen Detection Assay. (19th October 2020)

• Record Type: Journal Article
• Authors: Ly, Vo Trieu; Thanh, Nguyen Tat; Thu, Nguyen Thi Mai; Chan, Jasper; Day, Jeremy N; Perfect, John; Nga, Cao Ngoc; Vinh Chau, Nguyen Van; Le, Thuy
• Is Part Of: Open forum infectious diseases. Volume 7:Number 11(2020)
• Publication Date: 2020-10-19
• Subjects: Mp1p EIA -- Penicillium marneffei -- penicilliosis -- Talaromyces marneffei -- talaromycosis; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa502
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Talaromyces marneffei causes fatal invasive mycosis in Southeast Asia. Diagnosis by culture has limited sensitivity and can result in treatment delay. We describe the use of a novel Mp1p enzyme immunoassay (EIA) to identify blood culture–negative talaromycosis, subsequently confirmed by bone marrow cultures. This EIA has the potential to speed diagnosis, enabling early therapy initiation.