Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial. (26th May 2021)

• Record Type: Journal Article
• Authors: Arzika, Ahmed M; Maliki, Ramatou; Abdou, Amza; Mankara, Alio K; Harouna, Abdoul N; Cook, Catherine; Hinterwirth, Armin; Worden, Lee; Zhong, Lina; Chen, Cindi; Ruder, Kevin; Zhou, Zhaoxia; Lebas, Elodie; O'Brien, Kieran S; Oldenburg, Catherine E; Le, Victoria; Arnold, Benjamin F; Porco, Travis C; Keenan, Jeremy D; Lietman, Thomas M; Doan, Thuy
• Is Part Of: Clinical infectious diseases. Volume 73:Number 7(2021)
• Page Start: 1292
• Page End: 1295
• Publication Date: 2021-05-26
• Subjects: azithromycin -- antibiotic resistance -- gut resistome -- mass drug distribution -- Niger -- preschool children; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab485
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs. Clinical trials registration: NCT02047981