Structure, composition and biological properties of fungal extracellular vesicles. (24th June 2021)

• Record Type: Journal Article
• Authors: Rizzo, Juliana; Taheraly, Adam; Janbon, Guilhem
• Is Part Of: MicroLife. Volume 2(2021)
• Publication Date: 2021-06-24
• Subjects: fungi -- extracellular vesicles -- pathogens -- intercellular communication -- virulence -- interkingdom communication; Microbiology -- Periodicals; 579.05
• DOI: 10.1093/femsml/uqab009
• Languages: English
• ISSNs: 2633-6693

Abstract

ABSTRACT: Extracellular vesicles (EVs) are lipidic nanosized particles that deliver a highly complex molecular cargo between cells and organisms and may serve numerous functions in intercellular communication, thereby influencing the evolution of microbial communities. Their roles in infectious diseases have been studied for a long time, comprising viral, bacterial, parasitic and to a less extent, fungal infections. Over the last few years, fungal EVs have become an increasingly active research field. Nevertheless, the understanding of EV functions during fungal infections poses challenging points, comprising the genetics regulating EV release, the EV structural and compositional complexity, the heterogeneity of the EV populations and their impact on host-pathogen interactions. This review explores the state-of-the-art investigations on fungal EVs and how this fast-evolving field can impact the development of new tools to fight fungal infections. Abstract : The study of fungal extracellular vesicles is a fast evolving field which will impact the development of new tools to fight fungal infections in the future.