Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size. (28th June 2021)

• Record Type: Journal Article
• Authors: Ismail, Sherazaan D; Riou, Catherine; Joseph, Sarah B; Archin, Nancie M; Margolis, David M; Perelson, Alan S; Cassidy, Tyler; Abrahams, Melissa-Rose; Moeser, Matthew; Council, Olivia D; McKinnon, Lyle R; Osman, Farzana; Karim, Quarraisha Abdool; Abdool Karim, Salim S; Swanstrom, Ronald; Williamson, Carolyn; Garrett, Nigel J; Burgers, Wendy A
• Is Part Of: Clinical infectious diseases. Volume 73:Number 8(2021)
• Page Start: 1528
• Page End: 1531
• Publication Date: 2021-06-28
• Subjects: HIV-1 -- replication-competent virus -- reservoir -- T-cell activation; Communicable diseases -- Periodicals; 616.905
• DOI: 10.1093/cid/ciab587
• Languages: English
• ISSNs: 1058-4838

Abstract

Abstract: Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8 + T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.